Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205928 | 1.00 | MMP8 (0.48) | MMP8BLMCYP1A2ALDH1A1LMNA | |
| SCHEMBL5205923 | 1.00 | MMP8 (0.48) | MMP8BLMCYP1A2ALDH1A1LMNA | |
| SCHEMBL9386398 | 0.86 | BLM (0.63) | MMP8BLMCYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9386400 | 0.86 | BLM (0.63) | MMP8BLMCYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7362869 | 0.85 | MMP8 (0.59) | MMP8CYP1A2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1773480 | 0.84 | CYP3A4 (0.55) | MMP8BLMCYP1A2ALDH1A1LMNA | |
| SCHEMBL4299713 | 0.84 | CYP3A4 (0.55) | MMP8BLMCYP1A2ALDH1A1LMNA | |
| SCHEMBL1831636 | 0.84 | MMP8 (0.61) | MMP8BLMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10684512 | 0.84 | MMP8 (0.61) | MMP8BLMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7699138 | 0.84 | BLM (0.47) | BLMCYP1A2ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38132-E1 | Phenylpyrrolidines, phenylimidazolidines,3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-06-03 | — | — | US | disclosed |
| EP-0966447-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6355664-B1 | ADULT RESPIRATORY DISTRESS SYNDROME AND CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-03-12 | — | — | US | disclosed |
| US-6353013-B1 | ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-03-05 | — | — | US | disclosed |
| US-6350763-B1 | AND IMMUNE CELL-MEDIATED DISEASES; SELECTIVELY ANTAGONIZE THE BINDING OF THE CAMS TO THE LEUKOINTEGRINS; | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-02-26 | — | — | US | disclosed |
| WO-2001007048-A1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-02-01 | — | — | WO | disclosed |
| US-6043376-A | Synthesis of alpha-methyl, alpha-substituted amino acids | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0966447-A1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998039303-A1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1998-09-11 | — | — | WO | disclosed |