Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10902894 | 0.86 | TDP1 (0.44) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL6949538 | 0.81 | MAPT (0.50) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL13260526 | 0.81 | MAPT (0.40) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL11367939 | 0.79 | USP2 (0.47) | MAPTALDH1A1PDE7ATDP1TSHR | |
| SCHEMBL1193334 | 0.77 | ALDH1A1 (0.60) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL30458055 | 0.77 | ALDH1A1 (0.60) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL1192794 | 0.76 | MAPT (0.46) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL1192999 | 0.76 | MAPT (0.46) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL614284 | 0.75 | TDP1 (0.53) | MAPTALDH1A1PDE7AMEN1KMT2A | |
| SCHEMBL11548194 | 0.75 | ALDH1A1 (0.63) | MAPTALDH1A1PDE7AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |