Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967929 | 0.90 | NR1H2 (0.48) | NR1H2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL6962531 | 0.85 | NR1H2 (0.54) | NR1H2ACENAMPTHSD17B3HDAC8 | |
| SCHEMBL6961381 | 0.84 | ALDH1A1 (0.68) | NR1H2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL6974571 | 0.82 | NR1H2 (0.52) | NR1H2ACEHSD17B3HDAC8DPP8 | |
| SCHEMBL3858227 | 0.80 | NOTUM (0.63) | NR1H2HSD17B3HDAC8 | |
| SCHEMBL6973945 | 0.80 | NR1H2 (0.52) | NR1H2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL6972682 | 0.78 | NR1H2 (0.51) | NR1H2KDM4EACENAMPTHSD17B3 | |
| SCHEMBL6973919 | 0.78 | NR1H2 (0.51) | NR1H2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL381428 | 0.78 | NR1H2 (0.56) | NR1H2HSD17B3HDAC8 | |
| SCHEMBL6961235 | 0.77 | SGPL1 (0.51) | NR1H2KDM4EALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-0832069-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040640-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |