Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.75 |
| ▸ | EGFR | P00533 | 1/20 | 0.75 |
| ▸ | RAF1 | P04049 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | PRKCA | P17252 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | FRK | P42685 | 1/20 | 0.75 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.75 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.75 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.75 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.75 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907707 | 1.00 | MAPK14 (1.00) | MAPK14KDM4EMAPK13PRKD3MAP4K4 | |
| SCHEMBL6948154 | 0.95 | MAPK14 (0.90) | MAPK14BRD4BRDT | |
| SCHEMBL6949712 | 0.92 | MAPK14 (0.85) | MAPK14BRD4BRDT | |
| SCHEMBL6946216 | 0.91 | MAPK14 (0.84) | MAPK14MAPK13EGFRCSNK1DMAPK12 | |
| SCHEMBL6949268 | 0.90 | MAPK14 (0.81) | MAPK14BRD4BRDT | |
| SCHEMBL6949269 | 0.90 | MAPK14 (0.81) | MAPK14BRD4BRDT | |
| SCHEMBL4912070 | 0.90 | MAPK14 (1.00) | MAPK14BRD4BRDT | |
| SCHEMBL6970476 | 0.90 | MAPK14 (0.81) | MAPK14BRD4BRDT | |
| SCHEMBL4917866 | 0.88 | MAPK14 (1.00) | MAPK14BRD4BRDT | |
| SCHEMBL173596 | 0.86 | MAPK14 (1.00) | MAPK14KDM4EMAPK13PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900083-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-08-20 | — | — | EP | disclosed |
| US-5977103-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| US-5864036-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| US-5756499-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |