SCHEMBL6974548

SCHEMBL6974548

NC(=O)C1c2cc[c]cc2CCN1Cc1ccccc1Sc1ccc(Cl)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.38
CHRNA7 P36544 2/20 0.36
KDM4E B2RXH2 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A9 P48067 2/20 0.35
LMNA P02545 4/20 0.34
CYP2C9 P11712 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
HTR1A P08908 2/20 0.33
CYP2D6 P10635 2/20 0.33
HTR3A P46098 2/20 0.33
ALDH1A1 P00352 2/20 0.33
BLM P54132 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
NOD2 Q9HC29 1/20 0.33
HPGD P15428 1/20 0.32
CYP2C19 P33261 1/20 0.32
MAPT P10636 1/20 0.32
HDAC1 Q13547 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6975708 0.83 LMNA (0.40) LMNACYP1A2CYP3A4CYP2D6ALDH1A1
SCHEMBL6965675 0.82 SMN1; SMN2 (0.31) SMN1; SMN2HDAC1HDAC8
SCHEMBL6962637 0.82 GAA (0.39) LMNAALDH1A1NOD2HDAC1HDAC8
SCHEMBL6965745 0.80 EPHX2 (0.41) KDM4EALDH1A1HDAC8PPARGPPARD
SCHEMBL6964016 0.80 SIRT2 (0.39) KDM4ELMNAALDH1A1NPSR1L3MBTL1
SCHEMBL6966047 0.79 ESR1 (0.37) SMN1; SMN2CYP2C19HDAC1HDAC8PPARG
SCHEMBL6976521 0.78 GRM2 (0.41) LMNAHDAC1HDAC8HDAC6
SCHEMBL6969257 0.78 SMN1; SMN2 (0.39) SMN1; SMN2KDM4ELMNAALDH1A1NOD2
SCHEMBL6966200 0.76 PPARG (0.35) PPARGPPARDPPARA
SCHEMBL6972456 0.76 KDM4E (0.40) KDM4ECYP2C9CYP2C19MAPTHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832069-B1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER (US) 2003-03-05 EP disclosed