SCHEMBL6974751

SCHEMBL6974751

NC(=O)C1c2cc[c]cc2CCN1Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.40
CCR2 P41597 2/20 0.37
PPARG P37231 1/20 0.37
PPARD Q03181 1/20 0.37
PPARA Q07869 1/20 0.37
KMT2A Q03164 3/20 0.37
MEN1 O00255 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
OPRD1 P41143 1/20 0.36
POLB P06746 1/20 0.35
SIGMAR1 Q99720 3/20 0.35
MCHR1 Q99705 2/20 0.35
NPBWR1 P48145 1/20 0.35
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6962637 0.89 GAA (0.39) PPARGPPARDPPARAKMT2AMEN1
SCHEMBL6966200 0.87 PPARG (0.35) PPARGPPARDPPARASIGMAR1MCHR1
SCHEMBL6972456 0.86 KDM4E (0.40) PPARGPPARDPPARAKMT2AMEN1
SCHEMBL6966047 0.85 ESR1 (0.37) PPARGPPARDPPARAKMT2AMEN1
SCHEMBL6973731 0.85 ACACB (0.40) PPARGPPARDPPARAKMT2AMEN1
SCHEMBL6961872 0.84 GRM2 (0.41) KMT2AMEN1SIGMAR1MCHR1
SCHEMBL6966740 0.84 HDAC1 (0.39) PPARGPPARDPPARAKMT2AMEN1
SCHEMBL6969257 0.84 SMN1; SMN2 (0.39) KMT2AMEN1SMN1; SMN2KDM4EALDH1A1
SCHEMBL6972428 0.84 DRD2 (0.35) KMT2AMEN1KDM4EALDH1A1SIGMAR1
SCHEMBL6966889 0.83 HDAC3 (0.38) KMT2AMEN1KDM4EALDH1A1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832069-B1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER (US) 2003-03-05 EP disclosed
EP-1181954-A2 Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion PFIZER INC. (US) 2002-02-27 EP disclosed
EP-0832069-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996040640-A1 BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION PFIZER INC. (US) 1996-12-19 WO disclosed