SCHEMBL6974931

SCHEMBL6974931

C=C[C@H]1CN(CCCCCCC)CC[C@H]1CCCc1ccnc2ccc(OC)cc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 1/20 0.49
KCNH2 Q12809 6/20 0.44
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
CYP2D6 P10635 6/20 0.42
KDM4E B2RXH2 5/20 0.42
ALDH1A1 P00352 4/20 0.42
SLC22A1 O15245 3/20 0.42
ABCB11 O95342 3/20 0.42
ABCB1 P08183 3/20 0.42
ADRA2A P08913 3/20 0.42
SLC6A4 P31645 3/20 0.42
OPRM1 P35372 3/20 0.42
SCN1A P35498 3/20 0.42
SCN2A Q99250 3/20 0.42
SCN3A Q9NY46 3/20 0.42
CYP3A4 P08684 3/20 0.42
HSD17B10 Q99714 2/20 0.42
SLC22A2 O15244 2/20 0.42
MEN1 O00255 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6968167 1.00 CCR8 (0.49) CCR8KCNH2MTNR1AMTNR1BCYP2D6
SCHEMBL6966554 0.96 CCR8 (0.50) CCR8KCNH2MTNR1AMTNR1BCYP2D6
SCHEMBL6973010 0.96 CCR8 (0.50) CCR8KCNH2MTNR1AMTNR1BCYP2D6
SCHEMBL6971729 0.88 CCR8 (0.52) CCR8KCNH2MTNR1AMTNR1BCYP2D6
SCHEMBL6973637 0.88 ADRA1A (0.52) CCR8KCNH2CYP2D6KDM4EALDH1A1
SCHEMBL7814982 0.88 CCR8 (0.48) CCR8KCNH2MTNR1AMTNR1B
SCHEMBL7814983 0.88 CCR8 (0.48) CCR8KCNH2MTNR1AMTNR1B
SCHEMBL6968467 0.87 KCNH2 (0.43) CCR8KCNH2CYP2D6KDM4EALDH1A1
SCHEMBL6964557 0.87 ADRA1A (0.52) CCR8KCNH2CYP2D6KDM4EALDH1A1
SCHEMBL6968481 0.87 CCR8 (0.49) CCR8KCNH2CYP2D6KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051413-B1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-06-04 EP claimed
EP-1051413-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2000-11-15 EP claimed
WO-1999037635-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 1999-07-29 WO claimed
EP-1051413-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2000-11-15 EP disclosed
WO-1999037635-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 1999-07-29 WO disclosed