Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL27867074 | 0.98 | TDP1 (0.84) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| Styrene SCHEMBL7857368 | 0.92 | TDP1 (0.73) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL6035162 | 0.92 | TDP1 (0.95) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL94888 | 0.92 | TDP1 (0.95) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| Biphenyl SCHEMBL31074210 | 0.91 | TDP1 (0.78) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| Styrene SCHEMBL27847794 | 0.90 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| Styrene SCHEMBL27791421 | 0.90 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| Water SCHEMBL2898588 | 0.90 | TDP1 (0.91) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL28272951 | 0.90 | TDP1 (0.91) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL31126649 | 0.90 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023675-B2 | Polymer nanoparticles | ETH ZUERICH (CH) | 2018-07-17 | — | — | US | disclosed |
| US-20160024241-A1 | POLYMER NANOPARTICLES | ETH ZUERICH (CH) | 2016-01-28 | — | — | US | disclosed |
| US-9181358-B2 | Polymer nanoparticles | ETH ZUERICH (CH) | 2015-11-10 | — | — | US | disclosed |
| EP-2421903-B1 | POLYMER NANOPARTICLES | ETH ZUERICH (CH) | 2014-11-19 | — | — | EP | disclosed |
| WO-2014127179-A1 | MODIFIED HYDROPHOBIC SPONGES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2014-08-21 | — | — | WO | disclosed |
| US-20120115963-A1 | POLYMER NANOPARTICLES | ETH ZUERICH (CH) | 2012-05-10 | — | — | US | disclosed |
| EP-2421903-A1 | POLYMER NANOPARTICLES | ETH Zurich (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121387-A1 | POLYMER NANOPARTICLES | ETH Zürich (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-6559255-B2 | Using nitrone compound as controller | SYMYX TECHNOLOGIES INC. | 2003-05-06 | — | — | US | disclosed |
| US-20020013430-A1 | Controlled free radical emulsion and water-based polymerizations and seeded methodologies | FREESLATE, INC. | 2002-01-31 | — | — | US | disclosed |
| EP-1165625-A1 | CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES | Symyx Technologies, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000053640-A1 | CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES | SYMYX TECHNOLOGIES, INC. (US) | 2000-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024241-A1 | POLYMER NANOPARTICLES | POLQ, POLN, POLA1 | TDP1 1337/4885TSHR 4311/4885SMN1; SMN2 1318/4885 |
| US-10023675-B2 | Polymer nanoparticles | POLQ, POLN, POLA1 | TDP1 1337/4885TSHR 4311/4885SMN1; SMN2 1318/4885 |
| US-20120115963-A1 | POLYMER NANOPARTICLES | POLQ, POLN, POLA1 | TDP1 1337/4885TSHR 4311/4885SMN1; SMN2 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.