Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.73 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL27791421 | 0.98 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27847794 | 0.98 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL5538385 | 0.96 | TDP1 (0.68) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27867074 | 0.94 | TDP1 (0.84) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL27929378 | 0.93 | TDP1 (0.63) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL697500 | 0.92 | TDP1 (0.81) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL3095921 | 0.87 | TDP1 (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28993657 | 0.87 | TDP1 (0.61) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28958542 | 0.87 | TDP1 (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| Styrene SCHEMBL3134772 | 0.87 | TDP1 (0.67) | TDP1TSHRSMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118085482-A | Supermolecular polymer for impact-resistant material and preparation method thereof | 吉林大学 | 2024-05-28 | — | — | CN | claimed |
| CN-117143857-A | Free DNA extraction lysate and kit | 西安天隆科技有限公司 | 2023-12-01 | — | — | CN | claimed |
| CN-116180449-A | Synthesis method of modified polyurethane alumina fiber sizing agent main sizing agent and modified polyurethane alumina fiber sizing agent | 青岛汇智领先新材料科技有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-111910449-B | Warm-keeping fabric and preparation process thereof | 东莞世丽纺织有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-113684006-A | Preparation method of solid-liquid two-phase metal-polymer heat-conducting phase-change composite material | 东南大学 | 2021-11-23 | — | — | CN | claimed |
| CN-110774683-B | Fabric with low water washing shrinkage and preparation process thereof | 东莞世丽纺织有限公司 | 2021-11-12 | — | — | CN | claimed |
| CN-110511704-B | High-strength recyclable special plastic polymer composite adhesive, preparation method and application thereof | 吉林大学 | 2021-03-23 | — | — | CN | claimed |
| CN-109090720-B | Far infrared seamless body shaping clothes | 宏杰内衣股份有限公司 | 2020-11-13 | — | — | CN | claimed |
| CN-111910449-A | Warm-keeping fabric and preparation process thereof | 东莞世丽纺织有限公司 | 2020-11-10 | — | — | CN | claimed |
| CN-111910328-A | Moisture-absorbing and sweat-releasing fabric and preparation process thereof | 东莞世丽纺织有限公司 | 2020-11-10 | — | — | CN | claimed |
| CN-108017937-B | Preparation method of silane modified polyether sealant calcium carbonate | 广西华纳新材料科技有限公司 | 2020-06-23 | — | — | CN | claimed |
| CN-111041608-A | Dope-dyed sheath-core anti-ultraviolet flame-retardant water-repellent polyester fiber and preparation method thereof | 上海德福伦化纤有限公司 | 2020-04-21 | — | — | CN | claimed |
| CN-110774683-A | Fabric with low water washing shrinkage and preparation process thereof | 东莞世丽纺织有限公司 | 2020-02-11 | — | — | CN | claimed |
| CN-106748932-B | A kind of post-processing approach and device preparing methionine | 山东新和成氨基酸有限公司 | 2019-03-22 | — | — | CN | claimed |
| CN-104428387-B | Biodegradable graft copolymer anti-adhesion additive for water-based drilling fluids | 巴斯夫欧洲公司 | 2018-11-09 | — | — | CN | claimed |
| EP-2747744-B1 | ENHANCED PHOTOACTIVITY OF SEMICONDUCTORS AND/OR SUNSCREENS | EDGEWELL PERSONAL CARE BRANDS LLC (US) | 2018-06-06 | — | — | EP | claimed |
| CN-106748932-A | A kind of post-processing approach and device for preparing methionine | 山东新和成氨基酸有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-104428387-A | Biodegradable graft copolymer anti-accretion additives for water-based drilling fluids | BASF SE | 2015-03-18 | — | — | CN | claimed |
| CN-118085482-A | Supermolecular polymer for impact-resistant material and preparation method thereof | 吉林大学 | 2024-05-28 | — | — | CN | disclosed |
| JP-2001115328-A | CATIONIC DYE-DYEABLE VISCOSE RAYON | DAIWABO CO LTD | 2001-04-24 | — | — | JP | disclosed |