Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4936035 | 1.00 | MMP1 (0.36) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL4936029 | 1.00 | MMP1 (0.36) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL4938455 | 0.88 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2PTPN1HDAC8 | |
| SCHEMBL4938451 | 0.88 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2PTPN1HDAC8 | |
| SCHEMBL4945427 | 0.86 | HSD17B10 (0.39) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL4421987 | 0.86 | HSD17B10 (0.39) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL4421983 | 0.86 | HSD17B10 (0.39) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL4945424 | 0.86 | HSD17B10 (0.39) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL5946005 | 0.86 | HSD17B10 (0.39) | MMP1MMP3MMP7MMP13HSD17B10 | |
| SCHEMBL5743539 | 0.86 | HSD17B10 (0.39) | MMP1MMP3MMP7MMP13HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |