Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697538 | 1.00 | DPP4 (0.41) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL17227455 | 0.89 | DPP4 (0.44) | DPP4DPP7 | |
| SCHEMBL699084 | 0.88 | DPP4 (0.39) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL699083 | 0.88 | DPP4 (0.39) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL12971210 | 0.84 | DPP4 (0.44) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL30136577 | 0.84 | DPP4 (0.44) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL2572967 | 0.84 | DPP4 (0.44) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL30136576 | 0.84 | DPP4 (0.42) | DPP4 | |
| SCHEMBL344124 | 0.84 | DPP4 (0.42) | DPP4 | |
| SCHEMBL344125 | 0.84 | DPP4 (0.42) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |