Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699084 | 1.00 | DPP4 (0.39) | DPP4PIN1CASP3HTTFAP | |
| SCHEMBL697538 | 0.88 | DPP4 (0.41) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL697536 | 0.88 | DPP4 (0.41) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL3705644 | 0.88 | DPP4 (0.44) | DPP4PIN1MMEMMEL1 | |
| SCHEMBL29364846 | 0.83 | DPP4 (0.43) | DPP4PIN1 | |
| SCHEMBL342708 | 0.83 | DPP4 (0.43) | DPP4PIN1 | |
| SCHEMBL342707 | 0.83 | DPP4 (0.43) | DPP4PIN1 | |
| SCHEMBL28759095 | 0.83 | DPP4 (0.43) | DPP4PIN1 | |
| SCHEMBL463397 | 0.82 | DPP4 (0.38) | DPP4PIN1FAPDPP8DPP9 | |
| SCHEMBL25075296 | 0.82 | DPP4 (0.40) | DPP4PIN1FAPDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |