Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980576 | 0.96 | KCNJ1 (0.50) | KCNJ1KCNH2HRH3TSHRMAOA | |
| SCHEMBL11469205 | 0.84 | POLB (0.58) | KCNJ1KCNH2 | |
| SCHEMBL6974503 | 0.82 | HRH3 (0.44) | KCNJ1KCNH2HRH3TSHRMAOA | |
| SCHEMBL10376287 | 0.81 | POLB (0.53) | KCNJ1KCNH2HRH3TSHR | |
| SCHEMBL6968410 | 0.80 | HRH3 (0.43) | KCNJ1KCNH2HRH3TSHRMAOA | |
| SCHEMBL27708846 | 0.80 | POLB (0.49) | TSHR | |
| SCHEMBL6981979 | 0.77 | HRH3 (0.48) | HRH3 | |
| SCHEMBL28216834 | 0.77 | HRH3 (0.48) | HRH3 | |
| SCHEMBL21357469 | 0.77 | HRH3 (0.48) | HRH3 | |
| SCHEMBL27339117 | 0.77 | HRH3 (0.48) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |