Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979670 | 0.87 | EPHX1 (0.41) | HRH3EPHX1POLBLMNAGAA | |
| SCHEMBL6975448 | 0.82 | KCNJ1 (0.49) | HRH3TSHRKCNJ1KCNH2MAOA | |
| SCHEMBL6980576 | 0.80 | KCNJ1 (0.50) | HRH3TSHRKCNJ1KCNH2MAOA | |
| SCHEMBL6968410 | 0.78 | HRH3 (0.43) | HRH3TSHREPHX1KCNJ1KCNH2 | |
| SCHEMBL6981221 | 0.77 | POLB (0.45) | POLB | |
| SCHEMBL6976836 | 0.75 | GAA (0.40) | HRH3GAA | |
| SCHEMBL15964106 | 0.71 | KCNJ1 (0.56) | HRH3TSHRKCNJ1KCNH2MAOA | |
| SCHEMBL6978953 | 0.70 | NR1H4 (0.36) | — | |
| Hydrochloric Acid SCHEMBL14783255 | 0.70 | KCNJ1 (0.55) | HRH3TSHRKCNJ1KCNH2MAOA | |
| SCHEMBL6975226 | 0.69 | SLC18A3 (0.43) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |