Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970268 | 0.79 | APEX1 (0.53) | MEN1KMT2APDK2APEX1NPC1 | |
| SCHEMBL29441935 | 0.73 | APEX1 (0.64) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL29407802 | 0.73 | APEX1 (0.64) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL29407803 | 0.73 | APEX1 (0.64) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL7627154 | 0.73 | APEX1 (0.64) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL15691551 | 0.73 | MAPT (0.47) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL21996423 | 0.72 | ALDH1A1 (0.41) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL17051271 | 0.72 | APEX1 (0.62) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL28478377 | 0.72 | MAPT (0.46) | MAPTMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL15691742 | 0.72 | APEX1 (0.62) | MAPTMEN1KMT2ANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |