Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 4/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154052 | 0.80 | TGFBR1 (0.52) | MAPK13TGFBR1MAPK12MAPK11MAPK14 | |
| SCHEMBL4074281 | 0.77 | TGFBR1 (0.34) | TGFBR1MAPK14GRM5 | |
| SCHEMBL4085337 | 0.73 | TGFBR1 (0.34) | TGFBR1MAPK14GRM5 | |
| SCHEMBL4075747 | 0.71 | MEN1 (0.46) | MEN1KMT2AATMMAPK13TGFBR1 | |
| SCHEMBL6975683 | 0.70 | TGFBR1 (0.54) | MEN1KMT2AATMMAPK13TGFBR1 | |
| SCHEMBL29624091 | 0.70 | TGFBR1 (0.61) | MEN1KMT2AATMMAPK13TGFBR1 | |
| SCHEMBL4084260 | 0.70 | TGFBR1 (0.61) | MEN1KMT2AATMMAPK13TGFBR1 | |
| SCHEMBL6979584 | 0.70 | TGFBR1 (0.45) | MEN1KMT2AATMMAPK13TGFBR1 | |
| SCHEMBL13218171 | 0.69 | ATM (0.43) | MEN1KMT2AATMMAPK13TGFBR1 | |
| SCHEMBL5268022 | 0.68 | CHEK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169317-B1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6465493-B1 | SUCH AS 4-(4-(4-FLUOROPHENYL)-5-(2-PYRIDYL)-1-HYDROXY-1H-IMIDAZOL-2-YL)BENZONITRILE; ALK5 MEDIATED DISEASES SUCH AS ARTHRITIS, OSTEOPOROSIS, KIDNEY AND RENAL DISEASES, CONGES-TIVE HEART FAILURE, ULCERS, DIABETIC NEPHROPATHY | SMITHKLINE BEECHAM CORPORATION | 2002-10-15 | — | — | US | disclosed |
| EP-1169317-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061576-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-19 | — | — | WO | disclosed |