Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968275 | 0.99 | MAPK14 (0.56) | MAPK14RAF1HSPB1LYNLCK | |
| SCHEMBL6975166 | 0.92 | MAPK14 (0.65) | MAPK14RAF1HSPB1 | |
| SCHEMBL7835554 | 0.85 | MAPK14 (0.68) | MAPK14RAF1 | |
| SCHEMBL6969309 | 0.84 | MAPK14 (0.62) | MAPK14RAF1 | |
| SCHEMBL6975740 | 0.83 | MAPK14 (0.53) | MAPK14RAF1HSPB1LYNLCK | |
| SCHEMBL6970346 | 0.83 | MAPK14 (0.51) | MAPK14RAF1 | |
| SCHEMBL6968279 | 0.82 | MAPK14 (0.52) | MAPK14RAF1HSPB1LYNLCK | |
| SCHEMBL6483995 | 0.81 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL6477941 | 0.80 | MAPK14 (0.61) | MAPK14 | |
| SCHEMBL6979840 | 0.79 | HPGDS (0.61) | MAPK14RAF1HSPB1LYNLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | claimed |
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |