Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA4 | P22748 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975745 | 1.00 | NR1H2 (0.48) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL15020095 | 0.91 | NR1H2 (0.47) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL15020096 | 0.91 | NR1H2 (0.47) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL6099695 | 0.91 | NR1H2 (0.58) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL8240100 | 0.91 | SIGMAR1 (0.52) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL12780700 | 0.91 | SIGMAR1 (0.52) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL8448438 | 0.91 | NR1H2 (0.58) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL17376945 | 0.89 | NR1H2 (0.48) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL26915001 | 0.89 | NR1H2 (0.48) | NR1H2NR1H3PARP1AGTR2CA1 | |
| SCHEMBL4291170 | 0.89 | NR1H2 (0.48) | NR1H2NR1H3PARP1AGTR2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638936-B1 | Treatment of obesity in mammals, comprising administering to mammal in need of such treatment, treatment of obsessive compulsive disorder in mammals, comprising administering to a mammal treatment of depression in mammals | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1204658-B1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1204658-A1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009123-A1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |