Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979097 | 0.88 | HDAC1 (0.61) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL241664 | 0.86 | GSK3B (0.70) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL11043618 | 0.84 | HDAC8 (0.67) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL301099 | 0.82 | GSK3B (0.64) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL133319 | 0.82 | HDAC1 (0.75) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL27354009 | 0.80 | NPC1 (0.68) | HSP90AA1KCNH2ALDH1A1MAPTLMNA | |
| SCHEMBL25894500 | 0.80 | ALDH1A1 (0.65) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL3840781 | 0.80 | GSK3B (0.68) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL4496867 | 0.78 | GSK3B (0.59) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL100952 | 0.78 | NR4A2 (0.65) | GSK3BHDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104755077-B | Composition for preventing or treating kidney disease comprising pyrazole derivative | 梨花女子大学校产学协力团 | 2018-05-15 | — | — | CN | disclosed |
| CN-104755077-A | Composition for preventing or treating kidney disease comprising pyrazole derivative | UNIV EWHA IND COLLABORATION | 2015-07-01 | — | — | CN | disclosed |
| EP-1206262-A4 | NPY ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1206262-A1 | NPY ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6348472-B1 | ANOREXIGENIC AGENTS AND EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-19 | — | — | US | disclosed |
| WO-2001013917-A1 | NPY ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-01 | — | — | WO | disclosed |
| CN-1057674-C | Growth promoting composition and production thereof | KITASATO INST (JP) | 2000-10-25 | — | — | CN | disclosed |
| US-5854407-A | 15-hydroxy 6,9-hemiacetal erythromycin compounds | TAKEDA CHEMICAL CORPORATION (JP) | 1998-12-29 | — | — | US | disclosed |
| EP-0561413-B1 | Erythromycin deriatives, preparation and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5470961-A | 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives | TAKEDA CHEMICAL IND., LTD. (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0561413-A1 | Erythromycin deriatives, preparation and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-5175150-A | Stimulating digective contraction | KITASATO, KENKYUSHO (JP) | 1992-12-29 | — | — | US | disclosed |
| US-5008249-A | Administering anhydroerythromycin derivative | KITASATO KENKYUSHO (JP) | 1991-04-16 | — | — | US | disclosed |
| US-4948782-A | A method of promoting the growth of domestic animals with erythromycin derivative containing composition | KITASATO KENKYUSHO (JP) | 1990-08-14 | — | — | US | disclosed |
| CN-88101027-A | Growth promoting composition and preparation method thereof | — | 1988-08-31 | — | — | CN | disclosed |
| EP-0215355-A2 | Erythromycin derivative and process for preparing the same | KITASATO KENKYUSHO (JP) | 1987-03-25 | — | — | EP | disclosed |
| EP-0213617-A2 | Digestive tract contractile motion stimulant | KITASATO KENKYUSHO (JP) | 1987-03-11 | — | — | EP | disclosed |