Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.72 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377981 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6969701 | 0.83 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL9261161 | 0.80 | PTGS2 (0.60) | PTGS2PTGS1HTT | |
| SCHEMBL7612769 | 0.76 | PTGS2 (0.48) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL6977125 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6972308 | 0.75 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL1376982 | 0.75 | PTGS2 (0.84) | PTGS2PTGS1 | |
| SCHEMBL6967436 | 0.74 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL6973887 | 0.73 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL6975145 | 0.71 | PTGS2 (0.74) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518303-B2 | Selectively inhibit COX-2 in preference to COX-1 and are useful in the treatment of COX-2 mediated diseases, such as inflammation, pain, fever and asthma with fewer side effects | ALMIRALL PRODESFARMA S.A. (ES) | 2003-02-11 | — | — | US | disclosed |
| EP-1115716-B1 | 2-PHENYLPYRAN-4-ONE DERIVATIVES | ALMIRALL PRODESFARMA AG (CH) | 2003-01-02 | — | — | EP | disclosed |