Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 20/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229612 | 0.84 | HDAC4 (0.49) | HDAC4HDAC6HDAC8 | |
| SCHEMBL2227134 | 0.83 | HDAC4 (0.51) | HDAC4HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL2226598 | 0.83 | HDAC4 (0.48) | HDAC4HDAC6HDAC8HDAC1 | |
| SCHEMBL25301459 | 0.81 | TPMT (0.50) | — | |
| SCHEMBL31362829 | 0.81 | TPMT (0.50) | — | |
| SCHEMBL2224130 | 0.80 | HDAC4 (0.47) | HDAC4HDAC6HDAC8HDAC1 | |
| SCHEMBL2224875 | 0.79 | HDAC6 (0.59) | HDAC4HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL2225430 | 0.79 | HDAC4 (0.49) | HDAC4HDAC6HDAC8 | |
| SCHEMBL14645472 | 0.78 | HDAC4 (0.69) | HDAC4HDAC6HDAC8 | |
| SCHEMBL14645802 | 0.77 | HDAC4 (0.58) | HDAC4HDAC6HDAC8HDAC1HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088181-A9 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| WO-2011088181-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |