Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 14/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434405 | 0.88 | PLAU (0.71) | PLAURECQLTSHRLMNA | |
| SCHEMBL7375712 | 0.88 | PLAU (0.71) | PLAURECQLTSHRLMNA | |
| Hydrochloric Acid SCHEMBL6435890 | 0.87 | PLAU (0.70) | PLAURECQLTSHRLMNA | |
| SCHEMBL6434295 | 0.85 | PLAU (0.70) | PLAURECQLTSHRLMNAHCRTR1 | |
| Hydrochloric Acid SCHEMBL6433821 | 0.84 | PLAU (0.69) | PLAURECQLTSHRLMNAHCRTR1 | |
| Hydrochloric Acid SCHEMBL6434259 | 0.84 | PLAU (0.69) | PLAURECQLTSHRLMNAHCRTR1 | |
| SCHEMBL6437421 | 0.84 | PLAU (0.70) | PLAURECQLTSHRLMNAHCRTR1 | |
| SCHEMBL6977697 | 0.82 | PLAU (0.55) | PLAURECQLTSHRLMNAHCRTR1 | |
| SCHEMBL6434509 | 0.81 | PLAU (0.65) | PLAULMNA | |
| SCHEMBL6977110 | 0.80 | PLAU (0.71) | PLAURECQLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER (US) | 2003-01-08 | — | — | EP | claimed |