SCHEMBL6977053

SCHEMBL6977053

CC(OC([NH])=O)C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
GRM1 Q13255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6722116 0.81 TSHR (0.33) TSHRGRM1
SCHEMBL607855 0.78 TSHR (0.35) TSHRGRM1
SCHEMBL16659678 0.76 GRM1 (0.35) TSHRGRM1
SCHEMBL14752948 0.76 TSHR (0.52) TSHRGRM1
SCHEMBL607856 0.76 TSHR (0.33) TSHRGRM1
SCHEMBL1585487 0.76 TSHR (0.52) TSHRGRM1
SCHEMBL9384806 0.74 TSHR (0.32) TSHRGRM1
SCHEMBL15702222 0.74 PRKCA (0.42) TSHRGRM1
SCHEMBL6718011 0.74 TSHR (0.32) TSHRGRM1
SCHEMBL6718009 0.74 TSHR (0.32) TSHRGRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934938-B1 SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME ZERIA PHARM CO LTD (JP) 2003-01-15 EP disclosed
US-6121301-A ADMINISTERING TO PREVENT OR TREAT GASTROINTESTINAL DYSMOTILITY; COMPOUNDS SUCH AS 2-((N-(3-CYANOBENZOYL)AMINO)-4-((3-DIISOPROPYLAMINOPROPYL)AMINOCARBONYL)-1,3-THIAZOLE ZERIA PHARMACEUTICAL CO., LTD. (JP) 2000-09-19 US disclosed
EP-0934938-A1 SUBSTITUTED BENZOYLAMINOTHIAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-08-11 EP disclosed