Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977459 | 0.90 | LSS (0.93) | LSSNPC1HPGDALDH1A1L3MBTL1 | |
| SCHEMBL6981670 | 0.90 | LSS (0.76) | LSSNPC1LMNAL3MBTL1POLB | |
| SCHEMBL7336119 | 0.86 | LSS (1.00) | LSSLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1387275 | 0.85 | LSS (0.73) | LSSLMNAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL6184509 | 0.83 | LSS (0.77) | LSSL3MBTL1CHRM1CNR1 | |
| SCHEMBL6180071 | 0.82 | LSS (0.75) | LSSLMNASMN1; SMN2MAPK1HSD17B10 | |
| SCHEMBL6184180 | 0.82 | LSS (0.92) | LSSNPC1HPGDLMNAALDH1A1 | |
| Acetonitrile SCHEMBL6181195 | 0.81 | LSS (0.89) | LSSNPC1ALDH1A1L3MBTL1CHRM1 | |
| SCHEMBL6980850 | 0.80 | LSS (0.61) | LSSNPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1387187 | 0.79 | F10 (0.77) | LSSLMNASMN1; SMN2MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |