Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.93 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336119 | 0.96 | LSS (1.00) | LSSF10KMT2AL3MBTL1NPSR1 | |
| SCHEMBL6184180 | 0.92 | LSS (0.92) | LSSNPC1RAB9AHPGDALDH1A1 | |
| Acetonitrile SCHEMBL6181195 | 0.91 | LSS (0.89) | LSSNPC1RAB9AF10L3MBTL1 | |
| SCHEMBL6981670 | 0.91 | LSS (0.76) | LSSNPC1RAB9AF10KMT2A | |
| SCHEMBL6977162 | 0.90 | LSS (0.75) | LSSNPC1KMT2AL3MBTL1HPGD | |
| SCHEMBL6980904 | 0.85 | LSS (0.68) | LSSNPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL6977994 | 0.85 | LSS (0.93) | LSSNPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL6184509 | 0.84 | LSS (0.77) | LSSF10L3MBTL1NPSR1CNR1 | |
| SCHEMBL6180071 | 0.82 | LSS (0.75) | LSSF10NPSR1CNR1CHRM1 | |
| SCHEMBL7401658 | 0.82 | LSS (1.00) | LSSF10L3MBTL1CNR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |