Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977248 | 0.87 | PTGS2 (0.81) | PTGS2PTGS1MAPK14 | |
| SCHEMBL6974186 | 0.85 | PTGS2 (0.81) | PTGS2PTGS1MAPK14 | |
| SCHEMBL6982238 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL6976783 | 0.78 | PTGS2 (0.60) | PTGS2NPC1L3MBTL1ABCG2 | |
| SCHEMBL6978645 | 0.76 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL6970812 | 0.76 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL6976289 | 0.76 | PTGS2 (0.67) | PTGS2PTGS1L3MBTL1 | |
| SCHEMBL6981713 | 0.75 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL6981954 | 0.75 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL6978534 | 0.75 | PTGS2 (0.62) | PTGS2PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105384-B1 | DIARYLBENZOPYRAN DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-03-26 | — | — | EP | claimed |