Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.91 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.91 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.91 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.91 |
| ▸ | POLB | P06746 | 1/20 | 0.91 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18057759 | 0.95 | ADORA1 (0.82) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL6334237 | 0.95 | ADORA1 (0.82) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL27898 | 0.95 | ADORA2A (1.00) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL28634836 | 0.95 | ADORA2A (1.00) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL917182 | 0.95 | ADORA2A (1.00) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL29131394 | 0.93 | ADORA2A (0.95) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL11620040 | 0.93 | ADORA2A (0.95) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL8613754 | 0.93 | ADORA2A (0.95) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| SCHEMBL3424387 | 0.90 | ADORA2A (0.90) | ADORA1ADORA2AADORA3ADORA2BPOLB | |
| Benzoguanamine SCHEMBL110169 | 0.88 | ADORA2A (0.86) | ADORA1ADORA2AADORA3ADORA2BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | claimed |
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | disclosed |