Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 17/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.63 |
| ▸ | CCR5 | P51681 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977531 | 1.00 | OPRK1 (0.63) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| SCHEMBL6983806 | 0.90 | OPRK1 (0.61) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL6983811 | 0.90 | OPRK1 (0.61) | OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL17764962 | 0.89 | OPRK1 (0.75) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| SCHEMBL17764961 | 0.89 | OPRK1 (0.75) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| SCHEMBL6985662 | 0.89 | OPRK1 (0.64) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| SCHEMBL6985660 | 0.89 | OPRK1 (0.64) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL6478741 | 0.89 | OPRK1 (0.74) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| SCHEMBL6977756 | 0.87 | OPRK1 (0.58) | OPRK1CYP2D6CCR5OPRM1OPRD1 | |
| SCHEMBL6977759 | 0.87 | OPRK1 (0.58) | OPRK1CYP2D6CCR5OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817772-B1 | PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS | PFIZER (US) | 2003-01-29 | — | — | EP | claimed |
| EP-0817772-A1 | PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS | PFIZER INC. (US) | 1998-01-14 | — | — | EP | claimed |
| WO-1996030339-A1 | PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS | PFIZER INC. (US) | 1996-10-03 | — | — | WO | claimed |
| EP-0817772-B1 | PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS | PFIZER (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6110947-A | AN ANALGESIC AGENT FOR TREATING STROKE, ABDOMINAL PAIN; AS ANTIINFLAMMATORY, DIURETIC, ANESTHETIC OR NEUROPROTECTIVE AGENTS | PFIZER INC. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0982297-A2 | Process for the preparation of hydroxy-pyrrolidinyl hydroxamic acid derivatives being opioid kappa receptor agonists | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| US-6031114-A | Process for pyrrolidinyl hydroxamic acid compounds | PFIZER INC. (US) | 2000-02-29 | — | — | US | disclosed |
| WO-1996030339-A1 | PYRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND THEIR PRODUCTION PROCESS | PFIZER INC. (US) | 1996-10-03 | — | — | WO | disclosed |