Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | STAT3 | P40763 | 3/20 | 0.62 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | GALR3 | O60755 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968781 | 0.78 | F2 (0.62) | — | |
| SCHEMBL27333792 | 0.77 | LMNA (0.58) | LMNASTAT3NOD2POLBMAPT | |
| SCHEMBL7334269 | 0.75 | LMNA (0.59) | LMNASTAT3NOD2POLBMAPT | |
| SCHEMBL2559333 | 0.75 | HTT (0.60) | LMNAMAPTTSHRMAPK1ALDH1A1 | |
| SCHEMBL2559946 | 0.75 | MAPK1 (0.59) | LMNAPOLBMAPTMAPK1ALDH1A1 | |
| SCHEMBL5641073 | 0.74 | POLB (0.65) | LMNASTAT3NOD2POLBMAPT | |
| SCHEMBL8542772 | 0.74 | F2 (0.68) | LMNASTAT3NOD2POLBMAPT | |
| SCHEMBL6966460 | 0.74 | HPGD (0.46) | LMNAPOLBALOX15ALDH1A1HPGD | |
| SCHEMBL2558204 | 0.74 | KMT2A (0.72) | LMNAPOLBMAPTGALR3TSHR | |
| SCHEMBL7327289 | 0.74 | LMNA (0.56) | LMNASTAT3NOD2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021411-B1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6326386-B1 | ANTICOAGULANT | GLAXO GROUP LIMITED (GB) | 2001-12-04 | — | — | US | disclosed |
| EP-1021411-A1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997022589-A1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LIMITED (GB) | 1997-06-26 | — | — | WO | disclosed |