Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60903 | 0.80 | BRD4 (0.41) | FFAR3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2287208 | 0.78 | BRD4 (0.41) | FFAR3ALDH1A1SMN1; SMN2LMNAP2RX7 | |
| SCHEMBL16541489 | 0.78 | BRD4 (0.41) | FFAR3ALDH1A1SMN1; SMN2LMNAP2RX7 | |
| SCHEMBL29642954 | 0.78 | FFAR3 (0.37) | FFAR3ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL6887849 | 0.77 | FFAR3 (0.36) | FFAR3ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL12306235 | 0.77 | FFAR3 (0.36) | FFAR3ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL12987300 | 0.77 | FFAR3 (0.36) | FFAR3ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL1439148 | 0.77 | ALDH1A1 (0.38) | FFAR3ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL11172290 | 0.77 | GAA (0.38) | FFAR3ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL265557 | 0.76 | SMN1; SMN2 (0.45) | FFAR3ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268434-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074784-A1 | CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |