Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969088 | 0.92 | MAPK14 (0.61) | MAPK14SMO | |
| SCHEMBL6979521 | 0.86 | MAPK14 (0.58) | MAPK14SMORAF1BRAF | |
| SCHEMBL6486377 | 0.85 | MAPK14 (0.63) | MAPK14SMO | |
| SCHEMBL6972715 | 0.83 | MAPK14 (0.52) | MAPK14SMORAF1BRAF | |
| SCHEMBL6968599 | 0.82 | MAPK14 (0.51) | MAPK14SMORAF1BRAF | |
| SCHEMBL7805580 | 0.82 | MAPK14 (0.56) | MAPK14SMO | |
| SCHEMBL6968978 | 0.81 | MAPK14 (0.54) | MAPK14SMORAF1BRAF | |
| SCHEMBL6978092 | 0.80 | MAPK14 (0.54) | MAPK14SMORAF1BRAF | |
| SCHEMBL6979778 | 0.79 | MAPK14 (0.56) | MAPK14SMORAF1BRAF | |
| SCHEMBL6969091 | 0.78 | MAPK14 (0.42) | MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |