Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 5/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968599 | 0.96 | MAPK14 (0.51) | MAPK14SMORAF1BRAF | |
| SCHEMBL6976106 | 0.92 | MAPK14 (0.60) | MAPK14SMORAF1BRAF | |
| SCHEMBL6979521 | 0.90 | MAPK14 (0.58) | MAPK14SMORAF1BRAF | |
| SCHEMBL6974083 | 0.88 | MAPK14 (0.59) | MAPK14SMORAF1BRAF | |
| SCHEMBL6970752 | 0.85 | MAPK14 (0.66) | MAPK14SMORAF1BRAF | |
| SCHEMBL6476258 | 0.84 | OPRK1 (0.62) | MAPK14SMOLMNATP53MAPT | |
| SCHEMBL6978401 | 0.83 | MAPK14 (0.52) | MAPK14SMORAF1BRAF | |
| SCHEMBL6978609 | 0.81 | MAPK14 (0.68) | MAPK14SMORAF1BRAF | |
| SCHEMBL7828018 | 0.81 | MAPK14 (0.59) | MAPK14RAF1BRAF | |
| SCHEMBL7807945 | 0.81 | OPRK1 (0.56) | MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |