Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.72 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.71 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979267 | 0.87 | IGF1R (0.54) | EGFRROCK1ERBB3MEN1KMT2A | |
| SCHEMBL6969576 | 0.86 | EGFR (0.54) | EGFRROCK1ERBB3MEN1KMT2A | |
| SCHEMBL1377802 | 0.84 | EGFR (1.00) | EGFRROCK1MEN1KMT2AMAPT | |
| SCHEMBL12968972 | 0.83 | ROCK1 (1.00) | EGFRROCK1ERBB3MEN1KMT2A | |
| SCHEMBL6980608 | 0.82 | IGF1R (0.60) | EGFRROCK1IGF1R | |
| SCHEMBL4818944 | 0.82 | MAPT (0.69) | EGFRROCK1MEN1KMT2AMAPT | |
| SCHEMBL17915954 | 0.82 | EGFR (0.84) | EGFRROCK1ERBB3MEN1KMT2A | |
| SCHEMBL18083736 | 0.81 | EGFR (0.47) | EGFRROCK1ERBB3MEN1KMT2A | |
| SCHEMBL13166085 | 0.81 | NFKB1 (0.58) | EGFRROCK1MAPK1KDRPIK3CG | |
| SCHEMBL31046394 | 0.81 | EGFR (0.92) | EGFRROCK1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
| EP-0862560-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997019065-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |