Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924483 | 0.85 | DRD4 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL78044 | 0.85 | DRD4 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL27658505 | 0.84 | DRD2 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL21254392 | 0.84 | DRD4 (0.52) | SLC6A2SLC6A3SLC6A4DRD4CYP1A2 | |
| SCHEMBL18689815 | 0.84 | HRH1 (0.43) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL7497207 | 0.84 | DRD4 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL372608 | 0.84 | SLC6A2 (0.41) | GFERSLC6A2SLC6A3SLC6A4ADRB2 | |
| Water SCHEMBL27973306 | 0.83 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL21254378 | 0.82 | HRH3 (0.44) | MAOBMAOASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL27497060 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100338036-C | Substituted indolinones with inhibitory effect on kinase and cyclin complexes | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-09-19 | — | — | CN | disclosed |
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| CN-1303374-A | Substituted indolinones, process for their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-07-11 | — | — | CN | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |