Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | UTRN | P46939 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195816 | 0.84 | SMN1; SMN2 (0.79) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL12306754 | 0.81 | AAK1 (0.50) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL823534 | 0.80 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2HSD17B10TSHRHPGD | |
| SCHEMBL6984735 | 0.79 | SMN1; SMN2 (0.73) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL27477472 | 0.79 | SMN1; SMN2 (0.77) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL12306749 | 0.78 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL19441101 | 0.77 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL26206888 | 0.77 | NPY2R (0.43) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL12722044 | 0.76 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR | |
| SCHEMBL23451476 | 0.76 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2HSD17B10CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | ALDH1A1 1185/4885SMN1; SMN2 233/4885HSD17B10 1886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.