Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974845 | 0.91 | PTGS2 (0.72) | PTGS2CYP3A4MEN1ALOX15MAPK1 | |
| SCHEMBL6973940 | 0.89 | PTGS2 (0.69) | PTGS2ALDH1A1HPGDSMN1; SMN2MAPK14 | |
| SCHEMBL6977093 | 0.89 | PTGS2 (0.85) | PTGS2MAPK14PTGS1PLA2G2APLA2G4A | |
| SCHEMBL6970224 | 0.88 | PTGS2 (0.67) | PTGS2MEN1KMT2AMAPK14PTGS1 | |
| SCHEMBL6979358 | 0.88 | PTGS2 (0.67) | PTGS2ALDH1A1MAPK14PTGS1PLA2G2A | |
| SCHEMBL6975340 | 0.87 | PTGS2 (0.63) | PTGS2CYP3A4MEN1ALOX15MAPK1 | |
| SCHEMBL6973317 | 0.87 | PTGS2 (0.63) | PTGS2CYP3A4MEN1ALOX15MAPK1 | |
| SCHEMBL6978790 | 0.87 | PTGS2 (0.63) | PTGS2CYP3A4MEN1ALOX15MAPK1 | |
| SCHEMBL6979278 | 0.86 | MAPK14 (0.71) | PTGS2MAPK14PTGS1PLA2G2APLA2G4A | |
| SCHEMBL6976272 | 0.85 | PTGS2 (0.65) | PTGS2MAPK14PTGS1PLA2G2APLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105384-B1 | DIARYLBENZOPYRAN DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-03-26 | — | — | EP | claimed |
| US-6340694-B1 | Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors | PACIFIC CORPORATION (KR) | 2002-01-22 | — | — | US | claimed |
| CN-1323301-A | Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors | PACIFIC CORP (KR) | 2001-11-21 | — | — | CN | claimed |
| EP-1105384-B1 | DIARYLBENZOPYRAN DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-03-26 | — | — | EP | disclosed |
| US-6340694-B1 | Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors | PACIFIC CORPORATION (KR) | 2002-01-22 | — | — | US | disclosed |
| CN-1323301-A | Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors | PACIFIC CORP (KR) | 2001-11-21 | — | — | CN | disclosed |
| EP-1105384-A1 | DIARYLBENZOPYRAN DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010993-A1 | DIARYLBENZOPYRAN DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2000-03-02 | — | — | WO | disclosed |