Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.47 |
| ▸ | HRH2 | P25021 | 10/20 | 0.47 |
| ▸ | HRH1 | P35367 | 10/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5842455 | 0.92 | PTGER4 (0.44) | HRH3HRH2HRH1PTGER4 | |
| Fumaric Acid SCHEMBL5842461 | 0.92 | PTGER4 (0.44) | HRH3HRH2HRH1PTGER4 | |
| SCHEMBL6983793 | 0.81 | HRH3 (0.47) | HRH3HRH2HRH1 | |
| SCHEMBL6976146 | 0.80 | HRH3 (0.62) | HRH3HRH2HRH1 | |
| SCHEMBL5842805 | 0.79 | HRH3 (0.63) | HRH3HRH2HRH1 | |
| SCHEMBL5842536 | 0.78 | HRH3 (0.53) | HRH3HRH2HRH1 | |
| SCHEMBL6985236 | 0.75 | HRH3 (0.46) | HRH3HRH2HRH1 | |
| SCHEMBL6982698 | 0.74 | HRH3 (0.45) | HRH3HRH2HRH1 | |
| Fumaric Acid SCHEMBL5842845 | 0.74 | PTGER4 (0.42) | HRH3HRH2HRH1PTGER4 | |
| Fumaric Acid SCHEMBL5842842 | 0.74 | PTGER4 (0.42) | HRH3HRH2HRH1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |