Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741348 | 0.81 | GRM5 (0.62) | GRM5CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL1031985 | 0.81 | GRM5 (0.62) | GRM5CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL25699207 | 0.78 | GRM5 (0.68) | GRM5CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL3460454 | 0.78 | GRM5 (0.62) | GRM5CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL11810176 | 0.77 | SRD5A1 (0.47) | GRM5TYMS | |
| SCHEMBL10190650 | 0.77 | GRM5 (1.00) | GRM5CASP1CASP7HSD17B10ACACB | |
| SCHEMBL11812551 | 0.76 | SRD5A1 (0.49) | GRM5CYP11B1CYP11B2TYMS | |
| SCHEMBL11815365 | 0.76 | GRM5 (0.42) | GRM5CYP11B1CYP11B2 | |
| SCHEMBL11813917 | 0.76 | SRD5A1 (0.49) | GRM5CYP11B1CYP11B2TYMS | |
| SCHEMBL9014737 | 0.74 | TYMS (0.40) | GRM5TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12318756-B2 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | UNIVERSITEIT UTRECHT HOLDING B.V. (NL) | 2025-06-03 | — | — | US | disclosed |
| EP-3720597-B1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES | STICHTING TECHNISCHE WETENSCHAPPEN (NL) | 2023-11-29 | — | — | EP | disclosed |
| EP-3720597-B1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES | STICHTING TECHNISCHE WETENSCHAPPEN (NL) | 2023-11-29 | — | — | EP | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-11612877-B2 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-03-28 | — | — | US | disclosed |
| US-20200368721-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2020-11-26 | — | — | US | disclosed |
| US-20200368721-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2020-11-26 | — | — | US | disclosed |
| EP-3720597-A1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF | Stichting voor de Technische Wetenschappen (NL) | 2020-10-14 | — | — | EP | disclosed |
| WO-2019110557-A1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2019-06-13 | — | — | WO | disclosed |
| CN-103159735-B | The imidazoles kinase inhibitor replaced | TONGHUA JIDA PHARMACEUTICAL CO., LTD. (CN) | 2015-12-09 | — | — | CN | disclosed |
| CN-103159735-A | Substitutional imidazole kinase inhibitor | TONGHUA SIHUAN PHARM CO LTD | 2013-06-19 | — | — | CN | disclosed |
| EP-1119557-B1 | INDENO-, NAPHTO- AND BENZOCYCLOHEPTA DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6291486-B1 | PREVENTING OBESITY; ANORECTICS. | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-09-18 | — | — | US | disclosed |
| EP-1119557-A1 | INDENO-, NAPHTO- AND BENZOCYCLOHEPTA DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-08-01 | — | — | EP | disclosed |
| US-6090833-A | EATING DISORDERS; ANTIDIABETIC AGENT | AVENTIS PHARMA DEUTSCHAND GMBH (DE) | 2000-07-18 | — | — | US | disclosed |
| WO-2000018749-A1 | INDENO-, NAPHTO- AND BENZOCYCLOHEPTA DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |