SCHEMBL6979280

SCHEMBL6979280

O=C(O)Nc1ccc(C(=O)NNS(=O)(=O)c2ccccc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 5/20 0.73
KMT2A Q03164 5/20 0.72
MEN1 O00255 4/20 0.72
GAA P10253 7/20 0.64
KDM4E B2RXH2 1/20 0.64
HTT P42858 1/20 0.63
CYP3A4 P08684 1/20 0.56
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA9 Q16790 1/20 0.56
PKM P14618 1/20 0.56
ALDH1A1 P00352 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
HPGD P15428 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6986233 0.86 KAT6A (0.62) KAT6AKMT2AMEN1GAAKDM4E
SCHEMBL4765513 0.85 KAT6A (1.00) KAT6AKMT2AMEN1GAAHTT
SCHEMBL26104327 0.84 MEN1 (1.00) KAT6AKMT2AMEN1GAAHTT
SCHEMBL6400145 0.83 KAT6A (0.81) KAT6AKMT2AMEN1GAAHTT
SCHEMBL7234905 0.82 KAT6A (0.61) KAT6AKMT2AMEN1GAAKDM4E
SCHEMBL20233293 0.81 KAT6A (0.78) KAT6AKMT2AMEN1GAAHTT
SCHEMBL6396355 0.81 KAT6A (0.78) KAT6AKMT2AMEN1GAAHTT
SCHEMBL20233361 0.81 KAT6A (0.78) KAT6AKMT2AMEN1GAAHTT
SCHEMBL27460744 0.81 KAT6A (0.68) KAT6AKMT2AMEN1GAAKDM4E
SCHEMBL6394967 0.80 KAT6A (0.66) KAT6AKMT2AMEN1GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1044970-B1 Aminotriazole compounds, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2003-01-15 EP disclosed
EP-1044970-A1 Aminotriazole compounds, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2000-10-18 EP disclosed