Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.72 |
| ▸ | CNR1 | P21554 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654951 | 0.88 | LSS (0.72) | LSSCNR1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL6970581 | 0.88 | LSS (0.56) | LSSCNR1NPSR1F10ALDH1A1 | |
| SCHEMBL6975703 | 0.87 | LSS (0.53) | LSSALDH1A1L3MBTL1PKM | |
| SCHEMBL7085163 | 0.86 | LSS (0.69) | LSSCNR1NPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL6980904 | 0.85 | LSS (0.68) | LSSNPSR1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL7336119 | 0.84 | LSS (1.00) | LSSCNR1NPSR1F10ALDH1A1 | |
| SCHEMBL6978502 | 0.84 | LSS (0.52) | LSSCNR1NPSR1L3MBTL1NPC1 | |
| SCHEMBL6184369 | 0.82 | LSS (0.72) | LSSCNR1NPSR1F10ALDH1A1 | |
| SCHEMBL6977459 | 0.81 | LSS (0.93) | LSSCNR1NPSR1F10ALDH1A1 | |
| SCHEMBL6184180 | 0.80 | LSS (0.92) | LSSCNR1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| CN-1228087-A | Substituted pyrimidine derivatives and their pharmaceutical use | ZENECA LTD (GB) | 1999-09-08 | — | — | CN | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |