Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.54 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16088929 | 0.88 | DPP4 (0.60) | LMNATHRBDPP4DPP7S1PR1 | |
| SCHEMBL20853360 | 0.82 | NPC1 (0.59) | DPP4DPP7S1PR1S1PR3CASP3 | |
| SCHEMBL24386372 | 0.82 | DPP4 (0.52) | LMNATHRBDPP4DPP7S1PR1 | |
| SCHEMBL23558949 | 0.81 | RAB9A (0.51) | LMNADPP4S1PR1S1PR3SIRT2 | |
| SCHEMBL11020935 | 0.81 | SMN1; SMN2 (0.59) | LMNAS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL14153242 | 0.80 | RAB9A (0.54) | LMNADPP4S1PR1S1PR3SIRT2 | |
| SCHEMBL12188525 | 0.80 | SMN1; SMN2 (0.57) | LMNANPC1RAB9ATP53MAPT | |
| SCHEMBL12126068 | 0.80 | HTT (0.51) | LMNADPP4DPP7S1PR1S1PR3 | |
| SCHEMBL8592523 | 0.80 | HTT (0.51) | LMNAS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL20853053 | 0.79 | IDH1 (0.47) | DPP4DPP7S1PR1S1PR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | LMNA 1357/4885THRB 3278/4885DPP4 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.