Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | PAM | P19021 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979691 | 1.00 | MAPT (0.49) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6970192 | 0.99 | MAPT (0.48) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6980023 | 0.96 | ALDH1A1 (0.50) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6980019 | 0.96 | ALDH1A1 (0.50) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6980207 | 0.83 | ALDH1A1 (0.42) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6980209 | 0.83 | ALDH1A1 (0.42) | MAPTALDH1A1HPGDPOLBKDM4E | |
| Hydrochloric Acid SCHEMBL8063356 | 0.82 | ALDH1A1 (0.41) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6978566 | 0.82 | KDM4E (0.43) | MAPTALDH1A1HPGDPOLBKDM4E | |
| Hydrochloric Acid SCHEMBL6980357 | 0.82 | ALDH1A1 (0.41) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6966837 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1HPGDPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |