Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924847 | 0.84 | NOTUM (0.53) | KMT2AMEN1ATMPOLBSIRT3 | |
| SCHEMBL6965201 | 0.82 | KMT2A (0.55) | KMT2AMEN1ATMPOLBSIRT3 | |
| SCHEMBL925260 | 0.77 | SIRT1 (0.48) | KMT2APOLBSIRT3HSP90AA1PDK1 | |
| SCHEMBL24378124 | 0.77 | SIRT1 (0.52) | KMT2AMEN1POLBSIRT3HSP90AA1 | |
| SCHEMBL29516196 | 0.77 | SIRT1 (0.52) | KMT2AMEN1POLBSIRT3HSP90AA1 | |
| SCHEMBL924383 | 0.77 | SIRT1 (0.47) | KMT2AMEN1ATMPOLBSIRT3 | |
| SCHEMBL26938810 | 0.74 | KMT2A (0.46) | KMT2AMEN1ATMSIRT3SIRT1 | |
| SCHEMBL15452699 | 0.74 | POLB (0.60) | KMT2APOLBSIRT3HSP90AA1PDK1 | |
| SCHEMBL926521 | 0.73 | SIRT1 (0.47) | POLBHSP90AA1PDK1CYP2C9SIRT1 | |
| SCHEMBL924090 | 0.72 | POLB (0.46) | KMT2AMEN1POLBSIRT3HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-1140925-A1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040580-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINYL-METHYL[3-(1H-INDOL-3-YL)-ALKYL]-AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |