Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
| ▸ | MMP10 | P09238 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984594 | 0.94 | ADAM17 (0.43) | ADAM17APPTGFBR1MMP1MMP2 | |
| SCHEMBL6982297 | 0.91 | ADAM17 (0.42) | ADAM17APPTGFBR1MMP2MMP9 | |
| SCHEMBL6986737 | 0.91 | ADAM17 (0.43) | ADAM17APPTGFBR1MMP1MMP2 | |
| SCHEMBL6987554 | 0.89 | ADAM17 (0.42) | ADAM17APPTGFBR1MMP1MMP2 | |
| SCHEMBL6982207 | 0.89 | ADAM17 (0.42) | ADAM17TGFBR1CTSC | |
| SCHEMBL6988246 | 0.89 | ADAM17 (0.43) | ADAM17APPTGFBR1MMP1MMP2 | |
| SCHEMBL6988681 | 0.89 | ADAM17 (0.43) | ADAM17APPTGFBR1MMP2MMP9 | |
| SCHEMBL6987093 | 0.89 | ADAM17 (0.44) | ADAM17APPTGFBR1MMP2MMP9 | |
| SCHEMBL6987284 | 0.89 | ADAM17 (0.42) | ADAM17APPTGFBR1MMP2MMP9 | |
| SCHEMBL6986338 | 0.88 | ADAM17 (0.41) | ADAM17TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |