Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | GAA | P10253 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116026 | 0.85 | SMN1; SMN2 (0.54) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL3060022 | 0.83 | SMN1; SMN2 (0.57) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL15349917 | 0.79 | DYRK1A (0.65) | SMN1; SMN2RAB9AGAANPC1ALDH1A1 | |
| SCHEMBL16254915 | 0.76 | DYRK1A (0.71) | SMN1; SMN2RAB9AGAANPC1ALDH1A1 | |
| SCHEMBL6978735 | 0.76 | GAA (0.48) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL6979685 | 0.75 | GAA (0.47) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL3077601 | 0.74 | SMN1; SMN2 (0.67) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL6977213 | 0.73 | GAA (0.40) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL9258930 | 0.73 | SMN1; SMN2 (0.53) | HTR2CSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL2623678 | 0.73 | SMN1; SMN2 (0.61) | HTR2CSMN1; SMN2RAB9AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-1006114-A1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | Grelan Pharmaceutical Co., Ltd. (JP) | 2000-06-07 | — | — | EP | disclosed |