Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980243 | 1.00 | FOLH1 (0.42) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL6980245 | 1.00 | FOLH1 (0.42) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL5568919 | 0.83 | FOLH1 (0.38) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL6533837 | 0.83 | FOLH1 (0.38) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL6977776 | 0.82 | KMT2A (0.43) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL6977783 | 0.82 | KMT2A (0.43) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL6977780 | 0.82 | KMT2A (0.43) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL6984124 | 0.79 | FOLH1 (0.39) | FOLH1TPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL5887457 | 0.79 | ELANE (0.49) | FOLH1TPSAB1TPSD1TPSG1ELANE | |
| SCHEMBL4366611 | 0.79 | ELANE (0.49) | FOLH1TPSAB1TPSD1TPSG1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667772-B1 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | UNIV FLORIDA STATE (US) | 2003-05-14 | — | — | EP | disclosed |
| US-6521660-B2 | Anticancer, antitumor agents | FLORIDA STATE UNIVERSITY | 2003-02-18 | — | — | US | disclosed |
| US-6335362-B1 | ANTITUMOR AND ANTICARCINOGENIC AGENTS FOR LEUKEMIA | FLORIDA STATE UNIVERSITY | 2002-01-01 | — | — | US | disclosed |
| EP-1146043-A1 | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them | FLORIDA STATE UNIVERSITY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-1994010997-A1 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-05-26 | — | — | WO | disclosed |