Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5841481 | 0.99 | HTR1A (0.48) | HTR1ASLC6A4SIGMAR1TSHRKMT2A | |
| SCHEMBL5841552 | 0.81 | GRIN1 (0.55) | SIGMAR1KMT2ATMEM97GRIN1GRIN2B | |
| SCHEMBL6986329 | 0.80 | GRIN1 (0.57) | HTR1AGRIN1GRIN2BKCNH2 | |
| SCHEMBL5842866 | 0.80 | GRIN1 (0.54) | SIGMAR1KMT2ATMEM97GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL5840866 | 0.80 | GRIN1 (0.54) | SIGMAR1KMT2ATMEM97GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL5842816 | 0.79 | GRIN1 (0.56) | HTR1AGRIN1GRIN2BKCNH2 | |
| Hydrochloric Acid SCHEMBL5841279 | 0.79 | GRIN1 (0.53) | SIGMAR1KMT2AGRIN1GRIN2B | |
| SCHEMBL11805707 | 0.73 | HTR1A (0.52) | HTR1ASLC6A4SIGMAR1TSHRKMT2A | |
| SCHEMBL31033183 | 0.71 | KMT2A (0.56) | HTR1ASLC6A4SIGMAR1TSHRKMT2A | |
| SCHEMBL9247991 | 0.71 | HTR1A (0.56) | HTR1ASLC6A4TSHRKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |