Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | QRFPR | Q96P65 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28104559 | 0.74 | QRFPR (0.54) | QRFPRMEN1KMT2ALMNA | |
| SCHEMBL6980281 | 0.72 | MEN1 (0.40) | TACR1HRH3GNAI3QRFPRMEN1 | |
| SCHEMBL17979768 | 0.72 | CHRNB4 (0.58) | TACR1CHRNB4CHRNA3GNAI3 | |
| SCHEMBL18019869 | 0.72 | CHRNB4 (0.58) | TACR1CHRNB4CHRNA3GNAI3 | |
| SCHEMBL18019873 | 0.72 | CHRNB4 (0.58) | TACR1CHRNB4CHRNA3GNAI3 | |
| SCHEMBL10940416 | 0.71 | HPGD (0.48) | QRFPRMEN1KMT2A | |
| SCHEMBL11471256 | 0.70 | CHRNB4 (0.57) | TACR1CHRNB4CHRNA3GNAI3LMNA | |
| SCHEMBL7341529 | 0.67 | IDO1 (0.55) | MEN1KMT2A | |
| SCHEMBL28403191 | 0.67 | IDO1 (0.55) | LMNA | |
| SCHEMBL18019795 | 0.67 | CHRNB4 (0.64) | TACR1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |