Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975905 | 0.76 | TSHR (0.45) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6974616 | 0.76 | ADRA2A (0.43) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6982032 | 0.72 | TP53 (0.32) | — | |
| SCHEMBL2204596 | 0.69 | ADRA2A (0.56) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11484814 | 0.69 | ADRA2A (0.56) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL1568315 | 0.69 | HTT (0.60) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL3639837 | 0.67 | POLB (0.42) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL439092 | 0.66 | ADRA2A (0.60) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL20445516 | 0.66 | ADRA2A (0.56) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL568115 | 0.66 | ADRA2A (0.60) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |