Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980421 | 1.00 | DRD4 (0.43) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL6980427 | 1.00 | DRD4 (0.43) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL21468855 | 0.84 | ALDH1A1 (0.46) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL1044742 | 0.84 | ALDH1A1 (0.46) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL1018660 | 0.83 | ALDH1A1 (0.42) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL6978414 | 0.83 | ALDH1A1 (0.49) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL1019294 | 0.83 | ALDH1A1 (0.42) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL1019619 | 0.83 | ALDH1A1 (0.42) | DRD4ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL6978419 | 0.83 | ALDH1A1 (0.49) | ALDH1A1GLATP53CYP3A4TSHR | |
| SCHEMBL6978416 | 0.83 | ALDH1A1 (0.49) | ALDH1A1GLATP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |
| US-5935973-A | AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS | KNOLL AKTIENGESELLSCHAFT (DE) | 1999-08-10 | — | — | US | disclosed |